Central sensitization refers to dysfunction in the central nervous system (brain and spinal cord) which results in enhancement of pain sensations and can cause hypersensitivity to external stimuli (light, sound, scents, social stressors, etc.). Central sensitization has been implicated as a contributing factor in many chronic pain disorders. The Central Sensitization Inventory (CSI) was developed as a screener to help identify when a patient’s presenting symptoms may be related to central sensitization so proper assessment and treatment can be performed. In 2021 alone at least 80 CSI-related studies were published in peer-reviewed journals. There are currently 21 different language versions available, and more are expected to be published in 2022. All known language versions and additional CSI resources can be found at https://www.pridedallas.com/questionnaires/